Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Histamine Phosphate (Histamine acid phosphate) 是组胺受体的强激活剂和血管扩张神经剂,可激活一氧化氮合成酶。
规格 | 价格/CNY | 货期 | 数量 | |
---|---|---|---|---|
500 mg | ¥ 331 | 待询 | ||
1 g | ¥ 422 | 待询 |
Histamine Phosphate 的其他形式现货产品:
产品描述 | Histamine Phosphate (Histamine acid phosphate) acts directly on the blood vessels to dilate arteries and capillaries mediated by both H 1- and H 2-receptors. |
体外活性 | Histamine (10 μM) gives a larger inositol monophosphate accumulation in bovine adrenal chromaffin cells. Histamine (10 μM) stimulates the level of radioactivity into the InsP3-containing fraction in bovine adrenal chromaffin cells. Histamine (100 μM) stimulates incorporation into the InsP3-containing eluate in a less extent than for angiotensin I1 and bradykinin. [1] |
体内活性 | Histamine phosphate (0.025 mg/kg) produces a mean increase in basilar blood flow of 145% of control in dogs. Histamine phosphate produces considerable increases in basilar blood flow as well as a decrease in femoral arterial blood pressure in dogs when injected intravenously and measured with an electromagnetic flow transducer. [2] Histamine phosphate (4 μg/kg) causes lymph flow to increase from 6.0 to 27.0 (SEM) ml/h in unanesthetized sheep. Histamine phosphate (4 μg/kg) also causes increases in lung water, pulmonary vascular resistance, arterial PCO2, pH, and hematocrit, and decreases in cardiac output and arterial PO2 in unanesthetized sheep. [3] Histamine phosphate (8.3 mg/kg/min) causes no significant change in pulmonary lymph flow (QL) or protein concentration (CL) in anesthetized open-chested dogs, however, both are increased after alloxan. Histamine phosphate (8.3 mg/kg/min) also causes no significant change in the pulmonary capillary membrane filtration coefficient (Kf) and the maximum capillary pressure (PCcritical) in anesthetized open-chested dogs. [4] Histamine phosphate (50 mg/kg) produces a pronounced rise in acid secretion but the output of pepsin remained unchanged in the unanaesthetized intact rat. Histamine phosphate (50 mg/kg) produces maximal stimulation of gastric acid secretion and is free from toxic effects in the unanaesthetized intact rat. [5] |
别名 | 组胺磷酸盐, Histamine diphosphate, 二磷酸组胺, Histamine acid phosphate |
分子量 | 307.14 |
分子式 | C5H9N·2H3O4P |
CAS No. | 51-74-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 10 mM
DMSO: Insoluble
可选溶剂 | 浓度 体积 质量 | 1 mg | 5 mg | 10 mg | 25 mg |
H2O | 1 mM | 3.2558 mL | 16.2792 mL | 32.5584 mL | 81.3961 mL |
5 mM | 0.6512 mL | 3.2558 mL | 6.5117 mL | 16.2792 mL | |
10 mM | 0.3256 mL | 1.6279 mL | 3.2558 mL | 8.1396 mL |
对于不同动物的给药剂量换算,您也可以参考 更多...
请在以下方框中输入您的动物实验信息后点击计算,可以得到母液配置方法和体内配方的制备方法: 比如您的给药剂量是10 mg/kg,每只动物体重20 g,给药体积100 μL,一共给药动物10 只,您使用的配方为5% DMSO+30% PEG300+5% Tween 80+60% ddH2O。那么您的工作液浓度为2 mg/mL。
母液配置方法:2 mg 药物溶于 50 μL DMSO (母液浓度为 40 mg/mL), 如您需要配置的浓度超过该产品的溶解度,请先与我们联系。
体内配方的制备方法:取 50 μL DMSO 主液,加入 300 μL PEG300, 混匀澄清,再加 50 μL Tween 80,混匀澄清,再加 600 μL ddH2O, 混匀澄清。
您可能有的问题的答案可以在抑制剂处理说明中找到,包括如何准备库存溶液,如何存储产品,以及基于细胞的分析和动物实验需要特别注意的问题。
Histamine Phosphate 51-74-1 GPCR/G Protein Immunology/Inflammation Neuroscience Histamine Receptor inhibit Inhibitor 组胺磷酸盐 Histamine diphosphate Histamine acid Phosphate 二磷酸组胺 Histamine Diphosphate Histamine acid phosphate Histamine inhibitor